SPRAVATO®
Last Updated: December 12, 2025
What Is Spravato®
What is SPRAVATO® (esketamine) nasal spray?
REMS-certified, in-clinic treatment for adults with treatment-resistant depression (and certain urgent MDD cases).
SPRAVATO® is a prescription medicine used:
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- with or without an antidepressant taken by mouth, to treat adults with treatment-resistant depression (TRD)
- with an antidepressant taken by mouth, to treat depressive symptoms in adults with major depressive disorder (MDD) with suicidal thoughts or actions
SPRAVATO® is not for use as a medicine to prevent or relieve pain (anesthetic).It is not known if SPRAVATO® is safe or effective as an anesthetic medicine.
It is not known if SPRAVATO® is safe and effective for use in preventing suicide or in reducing suicidal thoughts or actions. SPRAVATO® is not for use in place of hospitalization if your healthcare provider determines that hospitalization is needed, even if improvement is experienced after the first dose of SPRAVATO®.
It is not known if SPRAVATO® is safe and effective in children. LEARN MORE ABOUT SPRAVATO®.
We Currently Accept BCBS PPO & Medicare for Spravato®.
Call: (815) 444-9999
(Medicaid and Medicaid MCOs are not accepted for Spravato® at this time.)
You May Be A Candidate if:
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- Are an adult with major depressive disorder and have not improved after trying two or more antidepressants at adequate dose/duration.
- Can remain on site ~2 hours of monitoring after each in-clinic dose.
- Will continue a daily oral antidepressant as prescribed.
- Have BCBS PPO or Medicare coverage.
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Note: Spravato® is not appropriate for everyone (e.g., certain vascular conditions, uncontrolled hypertension, pregnancy). Our team will review your history and coordinate with your prescriber.
How the Treatment Works
(3 Step Process)
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- Benefits Check & Medical Review — We verify coverage (BCBS PPO/Medicare only) and confirm medical eligibility.
- In-clinic Dosing & Monitoring — You self-administer nasal Spravato under supervision, then rest while we monitor you for ~2 hours.
- Follow-Up & Coordination — We update your referring clinician and adjust the plan as needed.
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Disclaimer: Information is educational and not a substitute for medical advice; eligibility determined by our medical team.
Safety & REMS
Spravato® is available only through a REMS program and must be administered in a clinic with observation. Common side effects can include transient dissociation, dizziness, nausea, and blood-pressure changes. A ride home is required after each session. We review risks, consent, and what to expect before you start.
Clinicians (Referrals)
Refer a patient (BCBS PPO/Medicare only): We provide REMS-certified administration, monitor for ~2 hours,
Fax: 815-986-1363
Phone: (815) 444-9999
Please Include: diagnosis, prior antidepressant trials (dose/duration), current medications, relevant medical history, and payer information.
Mathers Clinic – Crystal Lake
Call (815) 444-9999 to schedule or request a benefits check.
145 South Virginia Street, Crystal Lake, Illinois 60014
Monday – 8:00am – 7:00pm
Tuesday – 8:00am – 7:30pm
Wednesday – 8:00am – 6:00pm
Thursday – 8:00am – 5:00pm
Friday – 8:00am – 5:00pm
Saturday – 9:00am – 12:00pm
Sunday – Closed
We Currently Accept BCBS PPO & Medicare for Spravato®.
Call: (815) 444-9999
(Medicaid and Medicaid MCOs are not accepted for Spravato® at this time.)
Respectfully Caring for the Emotional Well Being of Individuals & Families.
Crystal Lake Office
145 South Virginia Street
Crystal Lake, Illinois 60014
phone: 815.444.9999
fax: 815.986.1363
Crystal Lake Business Hours
Monday 8:00am - 7:00pm
Tuesday 8:00am - 7:30pm
Wednesday 8:00am - 6:00pm
Thursday 8:00am - 5:00pm
Friday 8:00am - 5:00pm
Saturday 9:00am - 12:00pm
Sunday Closed
Woodstock Office
715 West Judd Street
Woodstock, Illinois 60098
phone: 815.444.9999
fax: 815.986.1363
Woodstock Business Hours
Monday 9:00am - 5:00pm
Tuesday 9:00am - 7:00pm
Wednesday Closed
Thursday 9:00am - 7:00pm
Friday 8:00am - 5:00pm
Saturday Closed
Sunday Closed
Elgin Office - New Location!
420 Airport Road, Suite C
Elgin, Illinois 60123
phone: 847.462.6099
fax: 847.628.6064
Elgin Business Hours
Hours Coming Soon!
Call 847.462.6099
for an Appointment
Mathers Community Mental Health Center Affiliates:
THE MATHERS RECOVERY
Federally licensed facilities for opiate/opioid treatment. Full range service for detoxification.
THE MATHERS CLINIC & MATHERS RECOVERY
Funding for this project was provided in partby the Kane County Health Department.
